Systems, Synthetic, and Physical Biology (SSPB) is emerging as one of the most important areas of life sciences of the 21st century to create technologies that transform agriculture, electronics, energy, information storage, medicine, and manufacturing. To realize the potential of engineered biological systems, we must understand the organizing principles of life through bottom-up synthetic biology and top-down systems biology studies. SSPB researchers operate at this interface, aiming to understand the physical biology language that determines the emergent behaviors of natural and engineered biological systems, such that new cellular functions can be reliably designed with robust characteristics that allow for meaningful applications.