Systems Biology

Rice University has over twenty Systems Biology Research Groups, which are working to understand the emergence of functional properties in complex biological systems that are not presented by the individual components, i.e., the individual genes, transcripts, proteins, and metabolites. These groups are interested in how biological networks give rise to emergent properties across a range of length scales. Many of these efforts are focused on human health, and numerous groups consider evolution of biological systems. A common theme among this research is the development of computational models and algorithms to understand and predict system properties.

bio network

Biological Networks

  • genetic-regulatory networks
  • metabolite networks
  • cell-fate determination
  • cellular organization in biofilms
  • host-pathogen interactions

human health

Human Health

  • allergies and inflammation
  • angiogenesis and neurogenesis
  • auditory systems
  • cancer and tumorigenesis
  • host defense against pathogens



  • genetics of human diseases
  • evolution of drug resistance
  • evolution and cancer
  • genome instability in evolution
  • speciation & adaptation

system approach

Systems Approaches

  • advanced imaging
  • bioreactors
  • genomic and metabolomics
  • microfluidics and micropatterning
  • network modeling